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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Life Sciences Development of New Reactions Using Organocatalyst Development of New Reactions Using Organocatalyst JAPANESEINQUIRY update：2020/06/16       NEXT PREV Features and Uniqueness Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure. Practical Application Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products. Keywords Synthetic Organic Chemistry Green Chemistry Asymmetric Synthesis Natural Product Chemistry Researchers Graduate School of Science Yujiro Hayashi, ProfessorDoctor of Science Laboratory Website researchmap Laboratory Website researchmap Related Information Publications1) High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations, H. Ishikawa, T. Suzuki, Y. Hayashi, Angew. Chem. Int. Ed., 48, 1304-1307 (2009). 2) Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes, Y. Hayashi, H. Gotoh, T. Hayashi, M. Shoji, Angew. Chem. Int. Ed., 44, 4212-4215 (2005). Browsing History Common Keywords Advanced Molecular Transformations by Organocatalysts [ 寺田 眞浩 教授 ] User Who Reviewed This Content Also Reviewed Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy [ SHIMOKAWA Hiroaki Professor ] Molecular Imaging from Basic Research to Clinical Application [ YANAI Kazuhiko Professor ] Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries [ Hiroshi Kanai Professor ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close