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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Integrative Life Sciences :Cellular Network Research HOME Research Researcher JAPANESE Professor TAGUCHI Tomohiko Campus Aobayama campus Laboratory Organelle Pathophysiology Tel +81-22-795-6676 E-mail tomohiko.taguchi.b8＠tohoku.ac.jp Google shcolar https://scholar.google.co.jp/citations?hl=ja&user=UxdBzqUAAAAJ   Our lab has just started since April 2018. We are interested in the function of intracellular organelles, in particular, the function of organelle membranes. Career 1992 B.Sc., Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo   1997 Ph.D., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo   1997-1999 Postdoctoral Fellow, RIKEN (Institute of Physical and Chemical Research)   1999-2004 Postdoctoral Fellow, Yale University School of Medicine   2004-2008 Associate Professor, Osaka University Graduate School of Medicine   2008-2010 Senior Research Officer, The University of Queensland   2011-2018 Associate Professor, The University of Tokyo   2018-Present Professor, Tohoku University Selected Publications 1. Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S., Iversen, M. B., Thielke, A. L., Gunderstofte, C., Motwani, M., Møller, C. T., Jakobsen, A., Fitzgerald, K. A., Roos, J., Lin, R., Maier, T. J., Goldback-Mansky, R., Miner, C. A., Qian, W., Miner, J., Rigby, R. E., Rehwinkel, J., Jakobsen, M. R., Arai, H., Taguchi, T., Schopfer, F. J., Olagnier, D., and Holm, C. K. (2018). Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. Proc. Natl. Acad. Sci. U S A 115, E7768-E7775. DOI: 10.1073/pnas.1806239115   2. Matsudaira, T., Mukai, K., Noguchi, T., Hasegawa, J., Hatta, T., Iemura, S. I., Natsume, T., Miyamura, N., Nishina, H., Nakayama, J., Semba, K., Tomita, T., Murata, S., Arai, H., and Taguchi, T. (2017). Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun 8, 1246. DOI: 10.1038/s41467-017-01255-3   3. Mukai, K., Konno, H., Akiba, T., Uemura, T., Waguri, S., Kobayashi, T., Barber, G. N., Arai, H., and Taguchi, T. (2016). Activation of STING requires palmitoylation at the Golgi. Nat Commun 7, 11932. DOI: 10.1038/ncomms11932   4. Lee, S., Uchida, Y., Wang, J., Matsudaira, T., Nakagawa, T., Kishimoto, T., Mukai, K., Inaba, T., Kobayashi, T., Molday, R. S., Taguchi, T., and Arai, H. (2015). Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase. EMBO J. 34, 669-688. DOI: 10.15252/embj.201489703   5. Maekawa, M., Terasaka, S., Mochizuki, Y., Kawai, K., Ikeda, Y., Araki, N., Skolnik, E. Y., Taguchi, T., and Arai, H. (2014). Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Proc. Natl. Acad. Sci. U S A 111, E978-87. DOI: 10.1073/pnas.1311029111   6. Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W. I., Taguchi, T., and Arai, H. (2011). Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc. Natl. Acad. Sci. U S A 108, 15846-15851. DOI: 10.1073/pnas.1109101108   7. Low, P. C., Misaki, R., Schroder, K., Stanley, A. C., Sweet, M. J., Teasdale, R. D., Vanhaesebroeck, B., Meunier, F. A., Taguchi, T., and Stow, J. L. (2010). Phosphoinositide 3-kinase delta regulates membrane fission of Golgi carriers for selective cytokine secretion. J. Cell Biol. 190, 1053-1065. DOI: 10.1083/jcb.201001028   8. Misaki, R., Morimatsu, M., Uemura, T., Waguri, S., Miyoshi, E., Taniguchi, N., Matsuda, M., and Taguchi, T. (2010). Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis. J. Cell Biol. 191, 23-29. DOI: 10.1083/jcb.200911143   9. Hieda, M., Isokane, M., Koizumi, M., Higashi, C., Tachibana, T., Shudou, M., Taguchi, T., Hieda, Y., and Higashiyama, S. (2008). Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane. J. Cell Biol. 180, 763-769. DOI: 10.1083/jcb.200710022   10. Ang, A. L., Taguchi, T., Francis, S., Folsch, H., Murrells, L. J., Pypaert, M., Warren, G., and Mellman, I. (2004). Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J. Cell Biol. 167, 531-543. DOI: 10.1083/jcb.200408165   11. Mitra, K., Ubarretxena-Belandia, I., Taguchi, T., Warren, G., and Engelman, D. M. (2004). Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc. Natl. Acad. Sci. U S A 101, 4083-4088. DOI: 10.1073/pnas.0307332101   12. Seemann, J., Pypaert, M., Taguchi, T., Malsam, J., and Warren, G. (2002). Partitioning of the matrix fraction of the Golgi apparatus during mitosis in animal cells. Science 295, 848-851. DOI: 10.1126/science.1068064 Activities in Academic Societies Japanese Biochemical Society, Japan Society for Cell Biology, The Japanese Conference on the biochemistry of lipids   Teaching Cell Biology (undergraduate), Life Science A (undergraduate), etc. Recent Activities * We revealed that STING, an essential protein for the type I interferon response against cytosolic DNA, is activated at the Golgi. The activation requires palmitoylation of STING. Our results may lead to new treatments for cytosolic DNA-triggered autoinflammatory diseases. Please see Mukai et al., Nat Commun 2016 for the details.   * We developed a novel method to identify organelle-resident proteins, which is based on the proximity-dependent biotin identification method. Please see Matsudaira et al., Nat Commun 2017 for the details. Message to Students Just feel free to contact me for any discussion on science! 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